The Infinite Plan, Isabel Allende.
Gregory is a lonely man, he doesn't know it for most of the novel but he is lonely and running from himself and his losses.As someone who has been this person I could entirely relate to the premise if not the individual circumstances behind this.
The Infinite Plan itself preaches of Karma-like experiences, what goes around comes around. You will see this reflected in the story. While the copyright for the English translation is 1993, you see much of this story reflected in our times, now. Gregory's story could be ours, the United States, story. In the way we don't always learn from our mistakes nor self regulate enough. We seem to overlook fundamental values for monetary values/ We could benefit from entertaining life as if we were humble peasants instead of facing life as if we were rulers of all kingdoms.
While staged in the U. S., this is an Isabel Allende novel. I would highly recommend it.